研究を行ったGiulio Maria Pasinetti博士とJun Wang 博士は、今回の結果は米食品医薬品局(FDA)による 食事指針の範囲内(女性1日1杯、男性1日2杯)で適量のワインを飲むことがアルツハイマー病のリスクを軽減させる という疫学的証拠を裏付けるものだと述べている。 この知見は、10月14〜18日にアトランタで開催予定の米国ニューロサイエンス年次集会でも発表される。
J. Wang, L. Ho, Z. Zhao, I. Seror, N. Humala, D. L. Dickstein, M. Thiyagarajan, S. S. Percival, S. T. Talcott, and G. M. Pasinetti Moderate consumption of Cabernet Sauvignon attenuates A neuropathology in a mouse model of Alzheimer's disease FASEB J 2006 20:
Moderate consumption of Cabernet Sauvignon attenuates As neuropathology in a mouse model of Alzheimer’s disease
Recent studies suggest that moderate red wine consumption reduces the incidence of Alzheimer’s disease (AD) clinical dementia. Using Tg2576 mice, which model AD-type amyloid beta-protein (As) neuropathology, we tested whether moderate consumption of the red wine Cabernet Sauvignon modulates AD-type neuropathology and cognitive deterioration. The wine used in the study was generated using Cabernet Sauvignon grapes from Fresno, California, and was delivered to Tg2576 in a final concentration of 6% ethanol.
We found that Cabernet Sauvignon significantly attenuated AD-type deterioration of spatial memory function and As neuropathology in Tg2576 mice relative to control Tg2576 mice that were treated with either a comparable amount of ethanol or water alone. Chemical analysis showed the Cabernet Sauvignon used in this study contains a very low content of resveratrol (0.2 mg/L), 10-fold lower than the minimal effective concentration shown to promote As clearance in vitro. Our studies suggest Cabernet Sauvignon exerts a beneficial effect by promoting nonamyloidogenic processing of amyloid precursor protein, which ultimately prevents the generation of As peptides.
This study supports epidemiological evidence indicating that moderate wine consumption, within the range recommended by the FDA dietary guidelines of one drink per day for women and two for men, may help reduce the relative risk for AD clinical dementia.?Wang, J., Ho, L., Zhao, Z., Seror, I., Humala, N., Dickstein, D. L., Meenakshisundaram, T., Percival, S. S., Talcott, S. T., Pasinetti, G. M. Moderate consumption of Cabernet Sauvignon attenuates As neuropathology in a mouse model of Alzheimer’s disease.