>Doesn’t this contradict Fig. 1i (see above) of the original Nature article that showed T cell receptor rearrangement? >Also the authors even in this new protocol paper refer to the cells of origin as “lymphocytes”.
I’m not an immunologist and perhaps I’m missing something so I’d curious if others with a deeper knowledge of T cells could weigh in here on the meaning of the author’s statement vs. the original paper.
On a simple level to me this new statement seems like a red flag, but perhaps others can clarify on the meaning and whether this suggests the authors are making STAP cells actually not from lymphocytes but rather from some kind of hematopoietic progenitor/stem cell.
OK, so what about the first 8 steps to make the STAP cells themselves?