[Analysis of serum zinc level in patients with atopic dermatitis, psoriasis vulgaris and in probands with healthy skin] [Article in German] Kreft B, Wohlrab J, Fischer M, Uhlig H, Skolziger R, Marsch WC. Martin-Luther-Universitat Halle/Wittenberg, Klinik und Poliklinik fur Hautkrankheiten, Ernst-Kromayer-Strasse 5-6, 06097 Halle, Saale.
BACKGROUND AND OBJECTIVE: The significance of zinc in the pathogenesis of different dermatological conditions is controversial. Using our own patient collective, the present study aimed to determine variations in serum zinc levels in patients with atopic dermatitis and psoriasis as compared to levels in the normal population. PATIENTS/METHODS: The serum zinc levels of 97 patients with atopic dermatitis and 88 patients with psoriasis were compared to those in 22 healthy subjects and subjected to statistical analysis. RESULTS: In contrast to the data given in the literature, no statistically significant difference was found between the populations investigated. CONCLUSIONS: Zinc replacement therapy in patients with atopic dermatitis and psoriasis appears to be indicated only in those with a documented zinc deficiency.
--------------------- お次はRCT。 Eur J Clin Nutr 1991 Oct;45(10):507-10 Failure of oral zinc supplementation in atopic eczema.
Ewing CI, Gibbs AC, Ashcroft C, David TJ. Department of Child Health, University of Manchester, U.K.
An eight week double-blind placebo-controlled trial of oral zinc sulphate 185.4 mg per day was undertaken in 50 children with atopic eczema aged 1-16 years. In those receiving zinc there was no significant improvement in disease severity as assessed by surface area affected and degree of erythema, symptom scores of itch, sleep disturbance and redness of skin, or weight of emollient or topical steroid use.